A teen with isotretinoin therapy should be monitored for which adverse effect?

• A. Depression
• B. Weight gain
• C. Hyperglycemia
• D. Nausea

Answer: (A)

A key safety concern with isotretinoin in teens is the risk of mood changes and depression. Adolescents on this medication should be regularly screened for signs of depressive symptoms because these can develop or worsen during therapy. Look for persistent sadness, irritability, withdrawal from friends or activities, sleep or appetite changes, or thoughts of self-harm. If such symptoms appear, stop the medication and seek timely psychiatric evaluation and support; coordination with a mental health professional is important.

Other common side effects of isotretinoin are typically skin- and metabolism-related, such as dryness of the lips and skin, and potential liver or lipid changes, but these do not carry the same level of concern for mood and suicidality in teens as depressive symptoms do.